Stress triggers key molecule to halt transcription of cell’s genetic code

27 mayo 2015

When cells are normal and unstressed, the molecule keeps transcription moving so that genes are «expressed» and RNA is jotted down more quickly. When cells are stressed and transcription runs into a glitch caused by damage to the DNA, it marks the machinery to be disassembled. Now, scientists and their collaborators have discovered how the molecule morphs between these two alternate identities, one as facilitator and the other as destroyer.