Blocking the PHD1 oxygen sensor hinders the activation of p53, a transcription factor that aids colorectal cancer (CRC) cells in repairing themselves and thus resisting chemotherapy, scientists have demonstrated. Chemotherapy resistance remains a major clinical issue in the treatment of CRC. These findings indicate that PHD1 inhibition may have valuable therapeutic potential.
http://www.sciencedaily.com/releases/2015/08/150819084153.htm
Reducing resistance to chemotherapy in colorectal cancer by inhibition of PHD1
19 agosto 2015
Volver