Inactive tumor suppressor gene discovered in lung cancer

14 abril 2015

The PARD3 gene has been identified by researchers as a tumor suppressor that is inactivated in lung cancer squamous type. PARD3 gene encodes a protein that regulates cell polarization and cell junctions. When the gene is inactivated, errors occur in this cell orientation and in contact with neighboring cells. «Any change affecting this structure promotes tumor development,» said a researcher.