Improved understanding of protein complex offers insight into DNA replication initiation mechanism basics

8 abril 2015

A clearer understanding of the origin recognition complex — a protein complex that directs DNA replication — through its crystal structure offers new insight into fundamental mechanisms of DNA replication initiation. This will also provide insight into how ORC may be compromised in a subset of patients with Meier-Gorlin syndrome, a form of dwarfism in humans.