How is the membrane protein folded? From molecular biology toward new medical care

2 marzo 2015

A key factor in the biosynthesis and stable expression of multi-pass transmembrane proteins has been discovered, and its loss is thought to cause retinal degeneration. The factor works especially for multi-pass membrane proteins, in the integration of polypeptides into the membrane and/or protein folding. Understanding the mechanisms underlying protein folding and trafficking may contribute to the large-scale, therapy-based production of target proteins.