Cancer risk linked to DNA ‘wormholes’

19 febrero 2015

Single-letter genetic variations within parts of the genome once dismissed as ‘junk DNA’ can increase cancer risk through wormhole-like effects on far-off genes, new research shows. Researchers found that DNA sequences within ‘gene deserts’ — so called because they are completely devoid of genes — can regulate gene activity elsewhere by forming DNA loops across relatively large distances.