Watching protein crystal nucleation in real time

21 enero 2015

A major hurdle in structural biology and pharmacology is growing crystals to determine the structure of the biomolecules and pharmaceuticals under study. Researchers have now observed a key step in the nucleation and growth of some protein crystals. For this, they exploited the power of in-situ real-time X-ray scattering techniques. Their study could help to gain a deeper understanding of protein crystallization and its kinetics on nanometer length scales. The researchers observed a multi-step crystallization mechanism.