Taking immortality away from cancer

13 mayo 2015

Researchers report that they have blocked the shelterin protein TRF1 in cancer cells, disrupting telomere protection and preventing immortal proliferation of cancer cells. Their work shows for the first time that telomeres — the structures protecting the ends of the chromosomes — may represent an effective anti-cancer target: by blocking the TRF1 gene, which is essential for the telomeres, they have shown dramatic improvements in mice with lung cancer.