T cell receptor ensures Treg functionality

8 enero 2015

Misdirected immune responses that target the body’s own tissue can result in diseases. Regulatory T cells combat this effect by suppressing excessive immune responses and responses against our own bodies. Until now, scientists had been aware of two molecular properties of regulatory T cells that control these functions. Now researchers have shown that signals emitted by T cell receptor on the regulartory T cells’ surface are also essential for their identity and suppressive functions.