Protein ‘brake’ in metabolic reprogramming restrains senescent cells from becoming cancerous

30 abril 2015

In recent years, research has shown that cancerous cells have a different metabolism — essential chemical and nutritional changes needed for supporting the unlimited growth observed in cancer– than normal cells. Now, scientists have identified a way that cells can reprogram their metabolism to overcome a tumor-suppressing mechanism known as senescence, solidifying the notion that altered metabolism is a hallmark of cancer progression.