Popular cancer drug target implicated in cardiovascular defects

8 septiembre 2014

Researchers have discovered an unlikely relationship between CXCR7 — a protein implicated in tumor growth and metastasis — and adrenomedullin — a hormone involved in cardiovascular health. Deleting CXCR7 allows adrenomedullin to run rampant, triggering the development of an enlarged heart and the overgrowth of the lymphatic vessels that traffic immune cells and fluids throughout the body.