New tool to study an important anti-cancer, immunosuppressive target

28 mayo 2015

The chemical rapamycin is used clinically as an immunosuppressant and as an anti-cancer agent that works by inactivating a protein named TOR (Target Of Rapamycin). This protein is essential for the growth of normal cells, but is hyperactive in tumor cells. To be able to carry out its various growth-related tasks, TOR needs to assemble into one of two larger protein complexes named TORC1 and TORC2. Curiously, whereas TORC1 is inhibited by rapamycin.