New target for anticancer drugs: RNA

6 abril 2015

Messenger RNAs — the working copies of genes that are used to assemble proteins — have typically been ignored as drug targets because they all look about the same. But researchers have found that a subset of mRNAs — many of which have been linked to cancer — have unique tags. These short RNA tags bind to a protein, eIF3, that regulates translation at the ribosome, making the binding site a promising target for anticancer drugs.