New, noncommittal mechanism of drug resistance discovered

27 julio 2014

Microorganisms like bacteria and fungi can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. These permanent mutations were once thought to be the only way for drug resistant strains to evolve. Now a new study has shown that microorganisms can use a temporary silencing of drug targets — known as epimutations — to gain the benefits of drug resistance without the commitment.