Engineering chimeric antigen receptor (CAR) T cells to lower their affinity for the protein epithelial growth factor receptor (EGFR) made the cells preferentially recognize and eliminate tumor cells that have high amounts of EGFR while sparing normal cells that have lower amounts of the protein, according to a preclinical study.
http://www.sciencedaily.com/releases/2015/09/150901095507.htm
Modified CAR T cells can preferentially target cancer cells, spare normal cells
1 septiembre 2015
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