Mechanism regulating gene expression linked to bone and joint damage in ankylosing spondylitis

12 junio 2015

A new study reveals that DNA methylation — a mechanism that regulates gene expression — could influence the progression of structural damage to the joints and spine in ankylosing spondylitis. Study findings showed significant associations between a low methylation score and more radiographic progression of the disease, and implicated smoking in worsening of disease outcome.