Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells

2 abril 2015

A particular molecular pathway permits stem cells in pediatric bone cancers to grow rapidly and aggressively, according to researchers. In the study, the investigators used human and mouse osteosarcomas to pinpoint the molecular mechanisms that inhibit the tumor-suppressive Hippo pathway. The researchers concluded that Sox2 represses the functioning of the Hippo pathway, which, in turn, leads to an increase of the potent growth stimulator Yes Associated Protein, known as YAP, permitting cancer cell proliferation.