Infection with multiple HIV-1 variants leads to poorer clinical outcomes

31 agosto 2015

HIV-1 infection with multiple founder variants points to poorer clinical outcomes than infection with a single variant, according to research. In the study, researchers analyzed large sample sets from two important HIV vaccine efficacy trials — the Step HIV vaccine clinical trial (HVTN 502) and RV144, the landmark vaccine clinical trial conducted in Thailand — to evaluate whether genetic characteristics of the founder viral populations could influence markers of clinical outcomes.