Eye development: Morphogenesis through flowing tissue

24 febrero 2015

In an in vivo analysis of eye development, researchers have gained fundamental new insight into the development of coloboma of the eye, prompting them to revise the classical view of the development of this sensory organ in vertebrates. The team used in vivo 4D microscopy to demonstrate that directed tissue flow transforms the optic vesicle into the optic cup during eye development. This is not only critical for understanding the cause of coloboma («cat eye syndrome»), but also means that eye development in vertebrates, including humans, is fundamentally different than has been taught for more than 70 years.