Histone deacetylase (HDAC) inhibitors have shown promise in ‘flushing out’ HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells. However, findings now suggest that treatment with HDAC inhibitors might suppress CTL activity and therefore compromise the ‘kill’ part of a two-pronged ‘flush-and-kill’ HIV eradication strategy.
http://feeds.sciencedaily.com/~r/sciencedaily/~3/79WQ3eC_8Gs/140814191945.htm
Drugs that flush out HIV may impair killer T cells, possibly hindering HIV eradication
14 agosto 2014
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