Drugs that flush out HIV may impair killer T cells, possibly hindering HIV eradication

14 agosto 2014

Histone deacetylase (HDAC) inhibitors have shown promise in ‘flushing out’ HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells. However, findings now suggest that treatment with HDAC inhibitors might suppress CTL activity and therefore compromise the ‘kill’ part of a two-pronged ‘flush-and-kill’ HIV eradication strategy.