Dr. Jekyll & Mr. Hyde: Telomere and telomerase in stem cells

19 mayo 2015

When a human cell divides, its’ daughter cells should each receive an identical copy of the mother cell’s genome. Occasionally mistakes occur during this process generating mutations that can give rise to cancer. To avoid detrimental outcome for the organism, cells with mutations that generate deviations from normal chromosomal number are eliminated by cellular protection mechanisms. Researchers have now identified a crucial role of telomeres, the end structures of chromosomes, for sensing cells with a wrong chromosome number, referred to as aneuploidy.