Double enzyme hit may explain common cancer drug side effect

12 octubre 2015

Many leukemias are caused by loss of the enzyme Pten. Some anti-leukemia treatments work by inhibiting another enzyme called Shp2. Researchers have now found that mice lacking both of these enzymes can’t produce and sustain enough red blood cells. The study helps explain why anemia is a common side effect of anti-cancer drugs that target enzymes involved in tumor growth.