Dialing a bespoke signal: New drug design works from outside the cell

16 marzo 2015

Exploring the fundamental mechanism by which a cell-surface receptor transmits its signal, an international team of researchers has established proof of concept for an entirely new approach to drug design. They report that a class of synthetic molecules known as diabodies can, from outside the cell, latch onto a target receptor and manipulate it in such a manner as to induce distinct and varying effects within cells and tissues.