Clues uncovered about how most important tuberculosis drug attacks its target

13 agosto 2014

A new clue to understanding how the most important medication for tuberculosis (TB) works to attack dormant TB bacteria in order to shorten treatment has been found by researchers. The antibiotic Pyrazinamide (PZA) has been used to treat TB since the 1950s, but its mechanisms are the least understood of all TB drugs. The PZA findings may help researchers identify new and more effective drugs not only for TB — which can require six months or more of treatment — but other persistent bacterial infections.