Chemo effect on brain cells pinpointed; potential link to autism

3 diciembre 2014

Scientists discovered how the chemo drug topotecan affects individual neurons to potentially cause «chemo fog.» A similar long-term affect in the developing brain could trigger autism. «There’s still a question in the cancer field about the degree to which some chemotherapies get into the brain,» said a co-senior author of the paper. «But in our experiments, we show that if they do get in, they can have a dramatic effect on synaptic function. We think drug developers should be aware of this when testing their next generation of topoisomerase inhibitors.»