Assortativity signatures of transcription factor networks contribute to robustness

29 agosto 2014

The type and number of connections in transcription factor networks (TFNs) have been studied to evaluate the role assortativity plays on robustness. The study found that the assortativity signature contributes to a network’s resilience against mutations. Transcription factors (TFs) are proteins that initiate and regulate the expression of a gene. To achieve their genetic mission, TFs also regulate one another’s expression.