
Alzheimer’s disease is associated with the appearance of characteristic neurotoxic protein aggregates in various regions in the brain. Chemical analysis of these insoluble deposits reveals that they are made up of a family of short protein fragments, referred to as beta-amyloid peptides, which are derived from a precursor protein called APP by the sequential action of two enzymes. Scientists have now made a discovery which extends this picture of the pathogenesis of Alzheimer’s disease, and has potentially far-reaching implications for our understanding of the condition.
http://www.sciencedaily.com/releases/2015/08/150831112504.htm