19 septiembre 2014
Crystals of membrane proteins and protein complexes often diffract to low resolution owing to their intrinsic molecular flexibility, heterogeneity or the mosaic spread of micro-domains. At low resolution, the building and refinement of atomic models is a more challenging task. The deformable elastic network refinement method developed previously has been instrumental in the determination of several structures at low resolution. Now, DEN refinement has been reviewed.
http://feeds.sciencedaily.com/~r/sciencedaily/~3/7v4eY0OVgpg/140919122214.htm
