{"id":20132,"date":"2015-04-02T12:16:26","date_gmt":"2015-04-02T12:16:26","guid":{"rendered":"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/"},"modified":"2015-04-02T12:16:26","modified_gmt":"2015-04-02T12:16:26","slug":"key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells","status":"publish","type":"rss_externo","link":"https:\/\/www.clpu.es\/en\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/","title":{"rendered":"Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells"},"content":{"rendered":"<p>A particular molecular pathway permits stem cells in pediatric bone cancers to grow rapidly and aggressively, according to researchers. In the study, the investigators used human and mouse osteosarcomas to pinpoint the molecular mechanisms that inhibit the tumor-suppressive Hippo pathway. The researchers concluded that Sox2 represses the functioning of the Hippo pathway, which, in turn, leads to an increase of the potent growth stimulator Yes Associated Protein, known as YAP, permitting cancer cell proliferation.<br \/><a href='http:\/\/feeds.sciencedaily.com\/~r\/sciencedaily\/~3\/x8eLNts6uVc\/150402081626.htm' title='Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells' target='_blank' rel=\"noopener\">http:\/\/feeds.sciencedaily.com\/~r\/sciencedaily\/~3\/x8eLNts6uVc\/150402081626.htm<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"class_list":["post-20132","rss_externo","type-rss_externo","status-publish","hentry","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells - CLPU<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells - CLPU\" \/>\n<meta property=\"og:description\" content=\"A particular molecular pathway permits stem cells in pediatric bone cancers to grow rapidly and aggressively, according to researchers. In the study, the investigators used human and mouse osteosarcomas to pinpoint the molecular mechanisms that inhibit the tumor-suppressive Hippo pathway. The researchers concluded that Sox2 represses the functioning of the Hippo pathway, which, in turn,&hellip; Continue reading Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"CLPU\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.clpu.es\\\/rss_externo\\\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\\\/\",\"url\":\"https:\\\/\\\/www.clpu.es\\\/rss_externo\\\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\\\/\",\"name\":\"Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells - CLPU\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.clpu.es\\\/#website\"},\"datePublished\":\"2015-04-02T12:16:26+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.clpu.es\\\/rss_externo\\\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.clpu.es\\\/rss_externo\\\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.clpu.es\\\/rss_externo\\\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/www.clpu.es\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"RSS externos\",\"item\":\"https:\\\/\\\/www.clpu.es\\\/rss_externo\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.clpu.es\\\/#website\",\"url\":\"https:\\\/\\\/www.clpu.es\\\/\",\"name\":\"CLPU\",\"description\":\"Centro de L\u00e1seres Pulsados\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.clpu.es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells - CLPU","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/","og_locale":"en_US","og_type":"article","og_title":"Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells - CLPU","og_description":"A particular molecular pathway permits stem cells in pediatric bone cancers to grow rapidly and aggressively, according to researchers. In the study, the investigators used human and mouse osteosarcomas to pinpoint the molecular mechanisms that inhibit the tumor-suppressive Hippo pathway. The researchers concluded that Sox2 represses the functioning of the Hippo pathway, which, in turn,&hellip; Continue reading Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells","og_url":"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/","og_site_name":"CLPU","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/","url":"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/","name":"Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells - CLPU","isPartOf":{"@id":"https:\/\/www.clpu.es\/#website"},"datePublished":"2015-04-02T12:16:26+00:00","breadcrumb":{"@id":"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.clpu.es\/rss_externo\/key-mechanism-identified-in-pediatric-bone-cancers-that-allows-proliferation-of-tumor-forming-stem-cells\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/www.clpu.es\/en\/"},{"@type":"ListItem","position":2,"name":"RSS externos","item":"https:\/\/www.clpu.es\/rss_externo\/"},{"@type":"ListItem","position":3,"name":"Key mechanism identified in pediatric bone cancers that allows proliferation of tumor-forming stem cells"}]},{"@type":"WebSite","@id":"https:\/\/www.clpu.es\/#website","url":"https:\/\/www.clpu.es\/","name":"CLPU","description":"Centro de L\u00e1seres Pulsados","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.clpu.es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.clpu.es\/en\/wp-json\/wp\/v2\/rss_externo\/20132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.clpu.es\/en\/wp-json\/wp\/v2\/rss_externo"}],"about":[{"href":"https:\/\/www.clpu.es\/en\/wp-json\/wp\/v2\/types\/rss_externo"}],"author":[{"embeddable":true,"href":"https:\/\/www.clpu.es\/en\/wp-json\/wp\/v2\/users\/2"}],"wp:attachment":[{"href":"https:\/\/www.clpu.es\/en\/wp-json\/wp\/v2\/media?parent=20132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}